Most PrEP users don’t experience side effects. In your first few weeks of taking PrEP, you might experience minor symptoms such as fatigue, headache, abdominal pain, and weight loss. These side effects should go away on their own.
A small number of PrEP users might be at increased risk for kidney disease. While you’re taking PrEP, your doctor will monitor your kidney function with routine blood tests every three months.